Itraconazole

Itraconazole
(Antifungals)

Dosage form	Brand	Strength
Capsule	Itra® Spornar® Itracon® Norspor®	100 mg

Indication : Tx of susceptible fungal infections including blastomycosis, histoplasmosis, aspergillosis and onychomycosis

Mechanism of action : Interferes with cytochrome P450 activity, decreasing ergosterol synthesis and inhibiting cell membrane formation.

Pregnancy Category C

Contraindication : Hypersensitivity to itraconazole.

Precaution  : Patients allergic to one azole antifungal agent.

Drug Interaction : astemizole, cisapride and terfenadine

Side Effect : gastrointestinal, nausea, diarrhea

Monitoring parameters : Liver function in patients with  pre-existing hepatic dysfunction.

Usual Dose : 100-400 mg/day; doses > 200 mg/day are given 2 divided dose.

Patient Education : checking with physician if no improvement within a few days, avoiding intake of alcoholic beverage, antacid

Missed Dose : Taking as soon as possible; not doubling doses; not taking if almost time for next dose.

Auxiliary labels  : Take with food. Continue medicine for full time of treatment.