Azathioprin
(Disease-Modifying Anti-Rheumatic Drugs)
(Disease-Modifying Anti-Rheumatic Drugs)
|
Dosage form
|
Brand
|
Strength
|
|
Tablet
|
Azathioprine
Pharmachemie®
|
50
mg
|
Indication
:
Prevention of rejection of kidney transplants, management of active RA
Mechanism
of action :
Antagonizes purine metabolism and may inhibit synthesis of DNA, RNA, and
proteins; may also interfere with cellular metabolism and inhibit mitosis.
Pregnancy
Category
D
Contraindication
: Hypersensitivity
to azathioprine or any component of the formulation; pregnancy with RA ; patients with RA and a history of treatment with
alkylating agents (eg. Cyclophosphamide, cholambucil, melphalan) may have a
prohibitive risk of neoplasia with azathioprine treatment.
Precaution
:
Chronic immunosuppression increases the risk of neoplasia and serious
infections.
Drug
Interaction : BCG; Febuxostat; Natalizumab; Pimecrolimus; Roflumilast;
Tacrolimus (Topical)
Side
Effect :
- Common side
effect :
Fever, malaise
-
Serious side effect :
Leukopenia, thrombocytopenia, Hepatoxicity, Myalgia, infection
Monitoring
parameters :
CBC, total bilirubin, liver function tests, TPMT genotyping or phenotyping
Usual
Dose:
-Renal transplantation Oral, I.V.: Initial :3-5 mg /kg/day usually given as a single daily
-Rheumatoid arthritis: Oral:Initial: 1 mg/kg/day given once daily or
divided twice daily for 6-8 weeks;
increase by 0.5mg/kg every 4 weeks until response or up to 2.5 mg/kg/day; an
adequate trial should be a minimum of 12 weeks.Maintenance dose: Reduce dose by
0.5 mg/kg every 4 weeks until lowest effective dose is reached; optimum
duration of therapy not specified; may be discontinued abruptly
Missed
Dose :
One dose a day-Do not take the missed dose at all and do not double the next
one and check with your doctor . More than one dose a day-Take the
missed as soon as you remember it. If it is time for your next dose, take both
doses together, then go back to your regular dosing schedule.
Auxiliary
labels : May be taken with or without food. (Preferably taken w/ or
after meals to reduce GI discomfort.)
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