Amiloride + Hydrochlorothiazide

Amiloride + Hydrochlorothiazide
(Potassium sparing diuretic + Thiazide diuretic)

Dosage form	Brand	Strength
Tablet	Amilozide®   Bilduretic®   Hydrozide plus®	Amiloride HCl 5 mg + hydrochlorothiazide 50 mg

Indication : Edema of cardiac origin, hepatic cirrhosis w/ ascites, HTN

Mechanism of action : Amiloride HCl inhibit Na⁺  reabsorption in the late distal convoluted tubules, connecting tubules, and collecting ducts in the kidneys. Hydrochlorothiazide increases excretion of Na⁺ and  Cl^- in approximately equivalent amounts.

Pregnancy Category B

Contraindication : Hyperkalemia, other concomitant antikaliuretic therapy or K supplementation, renal insufficiency

Precaution : Impaired hepatic & renal function, monitor for signs of fluid & electrolyte imbalance. May impair glucose tolerance, cause hyperkalemia or hypokalemia, precipitate hyperuricemia &/or gout. Increase in cholesterol & triglycerides

Drug Interaction : Alcohol, antidiabetics, antihypertensives, corticosteroids, ACTH, skeletal muscle relaxants, nondepolarizing drugs, NSAIDs, lithium

Side Effect : Headache, weakness, nausea, anorexia, rash & dizziness orthostatic effects

Monitoring parameters : assess weight, I&O reports daily to determine fluid loss; BP, serum electrolyte, BUN, creatinine

Usual Dose : Initially, 1-2 tab daily. Max: 4 tab. Should be taken with food.

Missed Dose : Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only the next regularly scheduled dose. It is not necessary to take a double dose.

Auxiliary labels  : This medicine causes frequent urination. This drug should not be taken at bedtime.

Do not eat salty foods and high salt or sodium foods. Do not take this medicine with potassium supplements or high potassium food.

 

ยาอันตราย Diuretics