Clarithromycin

Clarithromycin
(Antimycobacterial Drugs:Macrolide)

Dosage form	Brand	Strength
Tablet	Clacina® , Clacinia®, Clarith®	250 mg, 500 mg

Indication : Susceptible infections, Respiratory tract infections, Skin and soft tissue infections, Leprosy

Mechanism of action : Exerts its antibacterial action by binding to 50s ribosomal subunit resulting in inhibition of protein synthesis. The 14-OH metabolite of clarithromycin is twice as active as the parent compound against certain organisms.

Pregnancy Category D

Contraindication : Hypersensitivity to clarithromycin, erythromycin, or any macrolide antibiotic; use with ergot derivatives, pimozide, cisapride

Precaution : Dosage adjustment required with severe renal impairment; decreased dosaged or prolonged dosing interval may be appropriate. Use with caution in patients with myasthenia gravis.

Drug Interaction :  Alfuzosin; Artemether; BCG; Cisapride; Conivaptan; Dihydroergotamine; Dronedarone; Eplerenone; Ergotamine; Everolimus; Halofantrine; Lumefantrine; Nilotinib; Nisoldipine; Pimozide; Quinine; Ranolazine; Rivaroxaban

Side Effect : - Common side effect : Headache, rash, Abnormal taste, diarrhea, vomiting, nausea

                       - Serious side effect : Prothrombin time increase, BUN increase

Monitoring parameters : CBC, BUN, creatinine

Usual Dose : Children ≥ 6 months: Oral: 7.5 mg/kg every 12 hours (maximum: 500 mg/dose) for 10 days

                        Adults: 250-500 mg every 12 hours or 1000 mg (two 500 mg extended release tablets) once daily for 7-14 days

Missed Dose : If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your dosing schedule. Do not double doses.

Auxiliary labels  : Continue medicine for full time of treatment. May be taken with or without food.

ยาอันตราย บัญชี  ง: Macrolides