Simvastatin

Simvastatin
(Dyslipidaemic Agents)

Dosage form	Brand	Strength
Tablet	Zocor	5 mg , 10 mg  20 mg ,40 mg, 80 mg

Indication : reduce the risk of heart attack,prevent stroke and other heart disease

Mechanism of action : competitively inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase .

Pregnancy Category X

Contraindication : Hypersensitivity  to simvastatin or any component ,active liver disease ,unexplained persistent elevations of serum transaminases ,pregnancy; breast-feeding

Precaution  : increases in serum transaminases have occurred; liver function must be monitored by laboratory assessment

Drug Interaction : Protease Inhibitors: May increase the serum concentration of Simvastatin

Side Effect : Headache,insomnia, vertigo,muscle cramps, myalgia,myopathy. Serieous: rhabdomyolysis

Monitoring parameters : Creatine phosphokinase levels

Usual Dose : 20-40mg administered orally in evening without regard to meals

Patient Education : Avoid excessive concurrent use of alcohol, but abstinence is not required. Do not take these drugs during pregnancy because of possible harm to the fetus. Inform your physician if you become or intend to become pregnant.

Missed Dose : Take a missed dose as soon as you think about it. If it is close to time for the next dose, skip the missed dose and return to your normal time. Do not take two doses or extra doses. Do not change dose or stop drug. Talk with healthcare provider.

Auxiliary labels  : Avoid excessive concurrent use of alcohol.    

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