GPOvir Z250

GPOvir Z250
(Antivirals)

Dosage form	Brand	Strength
Tablet	GPOvir Z250®	Zidovudine 250 mg,Lamivudine 150 mg, Nevirapine 200 mg

Indication : treatment of HIV infections

Mechanism of action : Zidovudine and  lamivudine are NRTI , nevirapine  is NNRTI

Pregnancy Category Lamivudine : cat C , Zidovudine : cat C , Nevirapine : cat B

Contraindication : Life-threatening allergy to the drug or its components.

Precaution : Pregnancy; lactation. Use with caution in liver disease or hepatomegaly, especially in obese women.

Drug Interaction : Nevirapine CYP3A4 inducer

Side Effect : -Zidovudine Bone marrow suppression,anemia,nausea,abdominal pain, evaluted hepatic enzymes,headache, malaise,elevated CPK, myopathy

                       -Lamivudine Nausea, headache,fatigue, rash,anorexia

                       -Nevirapine Rash, hepatitis ,fatigue ,headache.

Monitoring parameters : ALT, AST, CBC,CD4⁺

Usual Dose : GPOvir 1 tab in morning and d4T+3TC in evening for14 day after that use GPOvir 2x2

Patient Education : This drug is not a cure for HIV disease. Opportunistic infections and other complications associated with HIV infection can continue to develop. This drug may be taken with food to decrease abdominal discomfort or nausea. It is important to have blood counts followed

closely during therapy to monitor for decreases in blood cell counts.