Niclosamide

Niclosamide
(Anthelmintics)

Dosage form	Brand	Strength
Tablet	Manoverm® Yomesan®  Telmitin®	500 mg

Indication : Tx. Tapewarm infestation

Mechanism of action : Inhibits oxidative phosphorylation of ATP by mitochondria or stimulation of ATPase activity.

Pregnancy Category B

Contraindication : Hypersensitivity to niclosamide.

Precaution : After taking niclosamide 2 hr then given laxative. Avoid alcohol between of treatment.

Drug Interaction  : Alcohol; niclosamide is soluble in alcohol. There increasing the absorption of drugs into the body. It can cause adverse reactions.

Side Effect : -Less common; Abdominal or stomach cramps or pain, diarrhea, loss of appetite, n/v.

                      -Rare; Dizziness or lightheadedness, drowsiness,ractal itching , skin rash, unpleasant taste.

Monitoring parameters : Stool examinations         

Usual Dose : First day; Adult and children>6 year 4 tab daily(initially 2 tab then 2 tab after 1 hr), 2-6 year 2 tab daily, <2 year 1 tab daily. For another six day; ½ given dosage.

Patient Education : Chew tablets thoroughly; tablets can be pulverized and mixed with water to form a paste for administration to children; can be taken with food; a mild laxative can be used for constipation.

Missed Dose : Taking ASAP; not taking if almost time for next scheduled dose. Do not double doses

Auxiliary labels  : The tablets are intended to be chewed before swallowing.

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