Paracetamol

Paracetamol
(Analgesics (Non-Opioid) & Antipyretics)

Dosage form	Brand	Strength
Caplet	Tylenol500 ®	500 mg

Indication: Tx of mild-to-moderate pain and fever (analgesic/antipyretic)

Mechanism of action : Inhibit the synthesis of prostaglandins in CNS , work peripherally to block pain impulse generation and produces antipyresis from inhibition of hypothalamic heat-regulating center.

Pregnancy Category B

Contraindication : Hypersensitivity to Paracetamol , severe hepatic impairment and severe active liver disease.

Precaution : Limit dose to < 4 g/day, may cause hepatotoxicity and liver damage ,use with caution in patient with liver disease

Drug Interaction :

-          Increase level of Paracetamol ; Conivaptan , Imatinib , Isoniazid , Metyrapone ,Probenacid

-          Decrease level of Paracetamol ; Hydantoin ,Barbiturate , Carbamazrpine

-          Paracetamol increase level of Vitamin K antagonist

Side Effect : Rash, anaphylaxis (rare), hypersensitivity reaction

Monitoring parameters : Relief of pain or fever

Usual Dose : 325-650 mg every 4-6 hours or 1000 mg 3-4 times/day; do not exceed 4 g/day

Patient Education : Most adverse effects are related to excessive use. Take with food or milk. While using this medication, avoid or limit alcohol to <3 drinks/day .

ยาทั่วไปไม่ได้อยู่ในกลุ่มวัตถุออกฤทธิ์ ยาเสพติด ยาควบคุมพิเศษหรืออันตราย บัญชี ก : Analgesics and antipyretics

Missed Dose : Take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

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